Clinical Data Ecosystem for Genomics (CDEG)
Status: Open
Posted date: July 17, 2025
Opportunity ID: 359208
Opportunity number: FOR-HG-26-005
Opportunity category: Discretionary
Agency name: National Institutes of Health
Agency code: HHS-NIH11
Award floor: $0
Award ceiling: $0
Cost sharing required: No
Funding Instrument Types
- Cooperative Agreement
Category of Funding Activity
- Health
Eligible Applicants
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities/Indian housing authorities
- Small businesses
- State governments
Categories (use these for quoted searches)
- agency_code:hhs_nih11
- category_of_funding_activity:health
- cost_sharing_or_matching_requirement:false
- eligible_applicants:county_governments
- eligible_applicants:for_profit_organizations_other_than_small_businesses
- eligible_applicants:independent_school_districts
- eligible_applicants:native_american_tribal_governments_federally_recognized
- eligible_applicants:native_american_tribal_organizations_other_than_federally_recognized_tribal_governments
- eligible_applicants:nonprofits_having_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
- eligible_applicants:private_institutions_of_higher_education
- eligible_applicants:public_and_state_controlled_institutions_of_higher_education
- eligible_applicants:public_housing_authoritiesindian_housing_authorities
- eligible_applicants:small_businesses
- eligible_applicants:state_governments
- funding_instrument_type:cooperative_agreement
- opportunity_category:discretionary
- status:open
The National Human Genome Research Institute (NHGRI) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research reduce barriers to a Clinical Data Ecosystem for Genomics (CDEG) by establishing a network to identify, share, and improve approaches for clinical integration and sharing of genome sequencing data and their interpretation as structured data among labs, health care providers, and patients. Specifically, the Network will: 1) establish a pilot ecosystem that demonstrates best practices for the sharing of genomic structured data (GSD) across different health care settings, including primary care; 2) create standardized application programming interfaces (APIs) to support access to such data; 3) develop open-source clinical software applications and databases that utilize these APIs; 4) demonstrate the ability of the pilot ecosystem to overcome barriers to accessing patient genomic data as patients travel across healthcare systems; and 5) refine and develop these practices into implementation resources for broader sharing and adoption. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of genomic medicine and implementation science are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in computational genomics and data science, electronic health records (EHR), genomic data standards, cloud and database development, health information exchange, and implementing genomics in clinical care will be encouraged and these investigators should also begin considering applying for this application.