PRIMED-AI: Multi-use Framework Playbooks (UG3 Clinical Trial Not Allowed)

Key Facts

Status: Open

Posted date: June 6, 2025

Opportunity ID: 359271

Opportunity number: NOT-RM-25-020

Opportunity category: Discretionary

Agency name: National Institutes of Health

Agency code: HHS-NIH11

Award floor: $0

Award ceiling: $0

Cost sharing required: No

Funding Instrument Types
  • Cooperative Agreement
Category of Funding Activity
  • Health
Eligible Applicants
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Small businesses
  • State governments
Tools
Categories (use these for quoted searches)
  • agency_code:hhs_nih11
  • category_of_funding_activity:health
  • cost_sharing_or_matching_requirement:false
  • eligible_applicants:county_governments
  • eligible_applicants:for_profit_organizations_other_than_small_businesses
  • eligible_applicants:independent_school_districts
  • eligible_applicants:native_american_tribal_governments_federally_recognized
  • eligible_applicants:native_american_tribal_organizations_other_than_federally_recognized_tribal_governments
  • eligible_applicants:nonprofits_having_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
  • eligible_applicants:private_institutions_of_higher_education
  • eligible_applicants:public_and_state_controlled_institutions_of_higher_education
  • eligible_applicants:public_housing_authoritiesindian_housing_authorities
  • eligible_applicants:small_businesses
  • eligible_applicants:state_governments
  • funding_instrument_type:cooperative_agreement
  • opportunity_category:discretionary
  • status:open
Description

The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’sPlaybook initiative will fund the development and initial testing of discrete projects that deliver “playbooks” of frameworks for responsible use of PRIMED-AI models, error mitigation and technical management of data and algorithms, data ontology/linkage, and preparation for regulatory approval (e.g., FDA). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3 activity code. Investigators with expertise and insights into AI-driven integration of clinical imaging with other complex and multiscale health data are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in harmonization processes for appropriate development and validation of multimodal AI tools to develop AI-based technologies leveraging multimodal data will be encouraged and these investigators should also begin considering applying for this application.

PRIMED-AI: Multi-use Framework Playbooks (UG3 Clinical Trial Not Allowed)
The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’sPlaybook initiative will fund the development and initial testing of discrete projects that deliver “playbooks” of frameworks for responsible use of PRIMED-AI models, error mitigation and technical management of data and algorithms, data ontology/linkage, and preparation for regulatory approval (e.g., FDA). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3 activity code. Investigators with expertise and insights into AI-driven integration of clinical imaging with other complex and multiscale health data are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in harmonization processes for appropriate development and validation of multimodal AI tools to develop AI-based technologies leveraging multimodal data will be encouraged and these investigators should also begin considering applying for this application.
PRIMED-AI: Multi-use Framework Playbooks (UG3 Clinical Trial Not Allowed)
Open
National Institutes of Health
Health
Cooperative Agreement
State governments
County governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
2025-06-06