PRIMED-AI: Translating Models to Clinic (UG3/UH3 Clinical Trial Optional)

Key Facts

Status: Open

Posted date: June 10, 2025

Opportunity ID: 359666

Opportunity number: NOT-RM-25-023

Opportunity category: Discretionary

Agency name: National Institutes of Health

Agency code: HHS-NIH11

Award floor: $0

Award ceiling: $0

Cost sharing required: No

Funding Instrument Types
  • Cooperative Agreement
Category of Funding Activity
  • Health
Eligible Applicants
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Small businesses
  • State governments
Tools
Categories (use these for quoted searches)
  • agency_code:hhs_nih11
  • category_of_funding_activity:health
  • cost_sharing_or_matching_requirement:false
  • eligible_applicants:county_governments
  • eligible_applicants:for_profit_organizations_other_than_small_businesses
  • eligible_applicants:independent_school_districts
  • eligible_applicants:native_american_tribal_governments_federally_recognized
  • eligible_applicants:native_american_tribal_organizations_other_than_federally_recognized_tribal_governments
  • eligible_applicants:nonprofits_having_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
  • eligible_applicants:private_institutions_of_higher_education
  • eligible_applicants:public_and_state_controlled_institutions_of_higher_education
  • eligible_applicants:public_housing_authoritiesindian_housing_authorities
  • eligible_applicants:small_businesses
  • eligible_applicants:state_governments
  • funding_instrument_type:cooperative_agreement
  • opportunity_category:discretionary
  • status:open
Description

The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s Translating Model to Clinic initiative will use a biphasic mechanism to initially focus on rigorous AI model building through the retrospective analysis and testing of large, interoperable multimodal datasets, laying a robust foundation for improved diagnostic accuracy, prognostic prediction, or therapeutic guidance where current methods fall short. Projects demonstrating strong potential and model readiness will advance to evaluating the real-world clinical utility of the AI-driven Clinical Decision Support (CDS) tool. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into analysis and testing of large, interoperable multimodal datasets are encouraged to begin to consider applying for this new NOFO.

PRIMED-AI: Translating Models to Clinic (UG3/UH3 Clinical Trial Optional)
The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s Translating Model to Clinic initiative will use a biphasic mechanism to initially focus on rigorous AI model building through the retrospective analysis and testing of large, interoperable multimodal datasets, laying a robust foundation for improved diagnostic accuracy, prognostic prediction, or therapeutic guidance where current methods fall short. Projects demonstrating strong potential and model readiness will advance to evaluating the real-world clinical utility of the AI-driven Clinical Decision Support (CDS) tool. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into analysis and testing of large, interoperable multimodal datasets are encouraged to begin to consider applying for this new NOFO.
PRIMED-AI: Translating Models to Clinic (UG3/UH3 Clinical Trial Optional)
Open
National Institutes of Health
Health
Cooperative Agreement
State governments
County governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
2025-06-10