Biomarkers of Cognitive Decline and Dementias of Aging in Individuals within the Autism Spectrum

Key Facts

Status: Open

Posted date: June 27, 2025

Opportunity ID: 359851

Opportunity number: FOR-TEMP-25653

Opportunity category: Discretionary

Agency name: National Institutes of Health

Agency code: HHS-NIH11

Award floor: $0

Award ceiling: $0

Cost sharing required: No

Funding Instrument Types
  • Cooperative Agreement
Category of Funding Activity
  • Health
Eligible Applicants
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Small businesses
  • State governments
Tools
Categories (use these for quoted searches)
  • agency_code:hhs_nih11
  • category_of_funding_activity:health
  • cost_sharing_or_matching_requirement:false
  • eligible_applicants:county_governments
  • eligible_applicants:for_profit_organizations_other_than_small_businesses
  • eligible_applicants:independent_school_districts
  • eligible_applicants:native_american_tribal_governments_federally_recognized
  • eligible_applicants:native_american_tribal_organizations_other_than_federally_recognized_tribal_governments
  • eligible_applicants:nonprofits_having_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
  • eligible_applicants:private_institutions_of_higher_education
  • eligible_applicants:public_and_state_controlled_institutions_of_higher_education
  • eligible_applicants:public_housing_authoritiesindian_housing_authorities
  • eligible_applicants:small_businesses
  • eligible_applicants:state_governments
  • funding_instrument_type:cooperative_agreement
  • opportunity_category:discretionary
  • status:open
Description

The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to invite applications to conduct observational studies in individuals living with Autism Spectrum Disorders (ASD) along the lifespan. The overarching goal is to determine the occurrence of age-related neurodegeneration across the heterogeneities of the ASD spectrum, characterize the physiopathology and manifestation of Alzheimer's disease (AD) and AD-related dementias (ADRD) in ASD, and, ultimately, develop precision-medicine strategies tailored to this understudied population. It is expected that proposed studies pursue deep phenotyping of aging individuals across the ASD spectrum, along with the characterization/validation of existing biomarkers of age-related cognitive decline and/or dementia in this population, and/or the discovery of novel ones. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO intends to utilize the U01 activity code. This NOFO encourages collaborations between investigators with expertise in autism and those with expertise in aging and dementia, fostering interactions between established centers for neurodevelopmental research and centers studying age-related cognitive decline.

Biomarkers of Cognitive Decline and Dementias of Aging in Individuals within the Autism Spectrum
The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to invite applications to conduct observational studies in individuals living with Autism Spectrum Disorders (ASD) along the lifespan. The overarching goal is to determine the occurrence of age-related neurodegeneration across the heterogeneities of the ASD spectrum, characterize the physiopathology and manifestation of Alzheimer's disease (AD) and AD-related dementias (ADRD) in ASD, and, ultimately, develop precision-medicine strategies tailored to this understudied population. It is expected that proposed studies pursue deep phenotyping of aging individuals across the ASD spectrum, along with the characterization/validation of existing biomarkers of age-related cognitive decline and/or dementia in this population, and/or the discovery of novel ones. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO intends to utilize the U01 activity code. This NOFO encourages collaborations between investigators with expertise in autism and those with expertise in aging and dementia, fostering interactions between established centers for neurodevelopmental research and centers studying age-related cognitive decline.
Biomarkers of Cognitive Decline and Dementias of Aging in Individuals within the Autism Spectrum
Open
National Institutes of Health
Health
Cooperative Agreement
State governments
County governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
2025-06-27