Multidisciplinary Research to Accelerate Hepatitis B Cure in Persons Living with HIV and HBV (MRA-HBV)

Key Facts

Status: Open

Posted date: June 27, 2025

Opportunity ID: 359860

Opportunity number: FOR-AI-27-017

Opportunity category: Discretionary

Agency name: National Institutes of Health

Agency code: HHS-NIH11

Award floor: $0

Award ceiling: $0

Cost sharing required: No

Funding Instrument Types
  • Cooperative Agreement
Category of Funding Activity
  • Health
Eligible Applicants
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Small businesses
  • State governments
Tools
Categories (use these for quoted searches)
  • agency_code:hhs_nih11
  • category_of_funding_activity:health
  • cost_sharing_or_matching_requirement:false
  • eligible_applicants:county_governments
  • eligible_applicants:for_profit_organizations_other_than_small_businesses
  • eligible_applicants:independent_school_districts
  • eligible_applicants:native_american_tribal_governments_federally_recognized
  • eligible_applicants:native_american_tribal_organizations_other_than_federally_recognized_tribal_governments
  • eligible_applicants:nonprofits_having_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
  • eligible_applicants:private_institutions_of_higher_education
  • eligible_applicants:public_and_state_controlled_institutions_of_higher_education
  • eligible_applicants:public_housing_authoritiesindian_housing_authorities
  • eligible_applicants:small_businesses
  • eligible_applicants:state_governments
  • funding_instrument_type:cooperative_agreement
  • opportunity_category:discretionary
  • status:open
Description

The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by soliciting applications to support Multidisciplinary Research to Accelerate Hepatitis B Cure in Persons Living with HIV (PLWH) and Hepatitis B Virus (HBV). This program will focus on: elucidating mechanisms of persistence and pathogenesis; discovering and developing clinically relevant biomarkers; discovering and/or validating host and/or new viral drug targets; and developing non-invasive diagnostics. Each MRA-HBV award will support an observational cohort paired with a multi-disciplinary teams focused on research that leverages samples from existing clinical data and sample repositories from previous cohort studies. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.

Multidisciplinary Research to Accelerate Hepatitis B Cure in Persons Living with HIV and HBV (MRA-HBV)
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by soliciting applications to support Multidisciplinary Research to Accelerate Hepatitis B Cure in Persons Living with HIV (PLWH) and Hepatitis B Virus (HBV). This program will focus on: elucidating mechanisms of persistence and pathogenesis; discovering and developing clinically relevant biomarkers; discovering and/or validating host and/or new viral drug targets; and developing non-invasive diagnostics. Each MRA-HBV award will support an observational cohort paired with a multi-disciplinary teams focused on research that leverages samples from existing clinical data and sample repositories from previous cohort studies. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Multidisciplinary Research to Accelerate Hepatitis B Cure in Persons Living with HIV and HBV (MRA-HBV)
Open
National Institutes of Health
Health
Cooperative Agreement
State governments
County governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
2025-06-27