Impact of Initial Influenza Exposure on Immunity in Infants

Key Facts

Status: Open

Posted date: July 8, 2025

Opportunity ID: 359939

Opportunity number: FOR-AI-27-024

Opportunity category: Discretionary

Agency name: National Institutes of Health

Agency code: HHS-NIH11

Award floor: $0

Award ceiling: $0

Cost sharing required: No

Funding Instrument Types
  • Cooperative Agreement
Category of Funding Activity
  • Health
Eligible Applicants
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Small businesses
  • State governments
Tools
Categories (use these for quoted searches)
  • agency_code:hhs_nih11
  • category_of_funding_activity:health
  • cost_sharing_or_matching_requirement:false
  • eligible_applicants:county_governments
  • eligible_applicants:for_profit_organizations_other_than_small_businesses
  • eligible_applicants:independent_school_districts
  • eligible_applicants:native_american_tribal_governments_federally_recognized
  • eligible_applicants:native_american_tribal_organizations_other_than_federally_recognized_tribal_governments
  • eligible_applicants:nonprofits_having_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
  • eligible_applicants:private_institutions_of_higher_education
  • eligible_applicants:public_and_state_controlled_institutions_of_higher_education
  • eligible_applicants:public_housing_authoritiesindian_housing_authorities
  • eligible_applicants:small_businesses
  • eligible_applicants:state_governments
  • funding_instrument_type:cooperative_agreement
  • opportunity_category:discretionary
  • status:open
Description

The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by continuing support to establish, follow, and characterize longitudinal cohorts of infants and/or mother-infant dyads to determine how influenza infections and/or vaccinations shape infant and childhood immunity. These studies will define and characterize immunity acquired upon initial exposure (including in utero) to influenza antigens from natural infections and/or vaccinations and examine how these exposures influence immune responses to subsequent influenza infections and/or vaccines. Projects that include mother-infant dyads will also study the role of maternal influenza immune status on neonatal responses to influenza infection and/or vaccination. The overall goal of this research is to provide key information to facilitate design of durable, broadly protective influenza vaccines. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.

Impact of Initial Influenza Exposure on Immunity in Infants
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by continuing support to establish, follow, and characterize longitudinal cohorts of infants and/or mother-infant dyads to determine how influenza infections and/or vaccinations shape infant and childhood immunity. These studies will define and characterize immunity acquired upon initial exposure (including in utero) to influenza antigens from natural infections and/or vaccinations and examine how these exposures influence immune responses to subsequent influenza infections and/or vaccines. Projects that include mother-infant dyads will also study the role of maternal influenza immune status on neonatal responses to influenza infection and/or vaccination. The overall goal of this research is to provide key information to facilitate design of durable, broadly protective influenza vaccines. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Impact of Initial Influenza Exposure on Immunity in Infants
Open
National Institutes of Health
Health
Cooperative Agreement
State governments
County governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
2025-07-08