Neural Ensembles & Used Substances (NExUS) Collaboratory : Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances
Status: Open
Posted date: September 11, 2025
Opportunity ID: 360562
Opportunity number: RFA-DA-27-010
Opportunity category: Discretionary
Agency name: National Institutes of Health
Agency code: HHS-NIH11
Award floor: $0
Award ceiling: $700,000
Cost sharing required: No
Funding Instrument Types
- Cooperative Agreement
Category of Funding Activity
- Health
Eligible Applicants
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities/Indian housing authorities
- Small businesses
- Special district governments
- State governments
Categories (use these for quoted searches)
- agency_code:hhs_nih11
- category_of_funding_activity:health
- cost_sharing_or_matching_requirement:false
- eligible_applicants:city_or_township_governments
- eligible_applicants:county_governments
- eligible_applicants:for_profit_organizations_other_than_small_businesses
- eligible_applicants:independent_school_districts
- eligible_applicants:native_american_tribal_governments_federally_recognized
- eligible_applicants:native_american_tribal_organizations_other_than_federally_recognized_tribal_governments
- eligible_applicants:nonprofits_having_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
- eligible_applicants:nonprofits_that_do_not_have_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
- eligible_applicants:others
- eligible_applicants:private_institutions_of_higher_education
- eligible_applicants:public_and_state_controlled_institutions_of_higher_education
- eligible_applicants:public_housing_authoritiesindian_housing_authorities
- eligible_applicants:small_businesses
- eligible_applicants:special_district_governments
- eligible_applicants:state_governments
- funding_instrument_type:cooperative_agreement
- opportunity_category:discretionary
- status:open
The National Institute on Drug Abuse (NIDA) seeks to advance its mission by supporting the expansion of the Collaboratory on Neural Ensembles & Used Substances (NExUS), an effort to build a knowledgebase of the neural cell populations and computations altered by substance-associated experiences, and underlying neurobehavioral states characteristic of addiction, or protective against it. This notice is provided to allow prospective applicants to develop applications that achieve the following goals:1) Collect and share granular datasets descriptive of neural cell populations tuned to tractable features of substance-related experiences2) Integrate cell-resolved readouts of ensemble activity with other granular data modalities (e.g., molecular cell identity, epigenetic state, morphology, spatial localization or connectivity)3) Develop tools for analysis and visualization of ensemble composition and geometry, and document their scalability4) Inform and test models for the mechanisms whereby cells or motifs are recruited into coding ensembles5) Enable synergies among NExUS-funded projects and with other cell atlasing efforts through coordination of outreach, data standards, analytics, common spatial frameworks, and reference taxonomiesGrant Authorities that allow NIDA to forecast this opportunity are as follows: Section 301 (42 U.S.C. § 241) and Section 405 (42 U.S.C. § 284).