Building Sustainable Software Tools for Open Science (R03 Clinical Trial Not Allowed)

Key Facts

Status: Open

Posted date: February 5, 2026

Opportunity ID: 361239

Opportunity number: RFA-OD-26-034

Opportunity category: Discretionary

Agency name: National Institutes of Health

Agency code: HHS-NIH11

Award floor: $0

Award ceiling: $0

Cost sharing required: No

Funding Instrument Types
  • Grant
Category of Funding Activity
  • Health
Eligible Applicants
  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Tools
Categories (use these for quoted searches)
  • agency_code:hhs_nih11
  • category_of_funding_activity:health
  • cost_sharing_or_matching_requirement:false
  • eligible_applicants:city_or_township_governments
  • eligible_applicants:county_governments
  • eligible_applicants:for_profit_organizations_other_than_small_businesses
  • eligible_applicants:independent_school_districts
  • eligible_applicants:native_american_tribal_governments_federally_recognized
  • eligible_applicants:native_american_tribal_organizations_other_than_federally_recognized_tribal_governments
  • eligible_applicants:nonprofits_having_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
  • eligible_applicants:nonprofits_that_do_not_have_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
  • eligible_applicants:others
  • eligible_applicants:private_institutions_of_higher_education
  • eligible_applicants:public_and_state_controlled_institutions_of_higher_education
  • eligible_applicants:public_housing_authoritiesindian_housing_authorities
  • eligible_applicants:small_businesses
  • eligible_applicants:special_district_governments
  • eligible_applicants:state_governments
  • funding_instrument_type:grant
  • opportunity_category:discretionary
  • status:open
Description

The Office of Data Science Strategy (ODSS) along with other NIH Institutes and Centers NEI, NHLBI, NHGRI, NIA, NIAAA, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIMH, NINDS, NIMHD, NLM, NCCIH, and NCI intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for renewal of the funding opportunity for Building Sustainable Software Tools for Open Science (RFA-OD-24-010).This funding opportunity is intended to provide a flexible mechanism to support the use of best practices and design principles for scientific software development/engineering and to promote community engagement for open science. Successful grants will enable and/or enhance biomedical, clinical, behavioral, social, and health-related research endeavors by (1) developing robust, sustainable, scalable, and reproducible research software tools and workflows, (2) extending the impact of research software by broader dissemination to the scientific community, (3) supporting collaborations between scientists and software engineers to leverage modern, best practices in research software development, and (4) enhancing software skills of the research workforce. This initiative is aligned with the NIH Strategic Plan for Data Science, which describes actions aimed at building a better data infrastructure and a modernized data ecosystem.No applications are being solicited at this time. Given the early expiration of RFA-OD-24-010, this notice will allow for potential applicants the opportunity to continue developing high-impact research software projects. Investigators with expertise and insights into this area of research software development are encouraged to consider applying for this new NOFO that will use the R03 activity code.

Building Sustainable Software Tools for Open Science (R03 Clinical Trial Not Allowed)
The Office of Data Science Strategy (ODSS) along with other NIH Institutes and Centers NEI, NHLBI, NHGRI, NIA, NIAAA, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIMH, NINDS, NIMHD, NLM, NCCIH, and NCI intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for renewal of the funding opportunity for Building Sustainable Software Tools for Open Science (RFA-OD-24-010).This funding opportunity is intended to provide a flexible mechanism to support the use of best practices and design principles for scientific software development/engineering and to promote community engagement for open science. Successful grants will enable and/or enhance biomedical, clinical, behavioral, social, and health-related research endeavors by (1) developing robust, sustainable, scalable, and reproducible research software tools and workflows, (2) extending the impact of research software by broader dissemination to the scientific community, (3) supporting collaborations between scientists and software engineers to leverage modern, best practices in research software development, and (4) enhancing software skills of the research workforce. This initiative is aligned with the NIH Strategic Plan for Data Science, which describes actions aimed at building a better data infrastructure and a modernized data ecosystem.No applications are being solicited at this time. Given the early expiration of RFA-OD-24-010, this notice will allow for potential applicants the opportunity to continue developing high-impact research software projects. Investigators with expertise and insights into this area of research software development are encouraged to consider applying for this new NOFO that will use the R03 activity code.
Building Sustainable Software Tools for Open Science (R03 Clinical Trial Not Allowed)
Open
National Institutes of Health
Health
Grant
State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others
2026-02-05