ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV

Key Facts

Status: Open

Posted date: February 6, 2026

Opportunity ID: 361255

Opportunity number: PAR-26-105

Opportunity category: Discretionary

Agency name: National Institutes of Health

Agency code: HHS-NIH11

Award floor: $0

Award ceiling: $0

Cost sharing required: No

Funding Instrument Types
  • Grant
Category of Funding Activity
  • Health
Eligible Applicants
  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Tools
Categories (use these for quoted searches)
  • agency_code:hhs_nih11
  • category_of_funding_activity:health
  • cost_sharing_or_matching_requirement:false
  • eligible_applicants:city_or_township_governments
  • eligible_applicants:county_governments
  • eligible_applicants:for_profit_organizations_other_than_small_businesses
  • eligible_applicants:independent_school_districts
  • eligible_applicants:native_american_tribal_governments_federally_recognized
  • eligible_applicants:native_american_tribal_organizations_other_than_federally_recognized_tribal_governments
  • eligible_applicants:nonprofits_having_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
  • eligible_applicants:nonprofits_that_do_not_have_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
  • eligible_applicants:others
  • eligible_applicants:private_institutions_of_higher_education
  • eligible_applicants:public_and_state_controlled_institutions_of_higher_education
  • eligible_applicants:public_housing_authoritiesindian_housing_authorities
  • eligible_applicants:small_businesses
  • eligible_applicants:special_district_governments
  • eligible_applicants:state_governments
  • funding_instrument_type:grant
  • opportunity_category:discretionary
  • status:open
Description

NICHD will advance its mission by using the DP2 mechanism to support early-career investigators conducting pioneering research on HIV-related chronic conditions, coinfections, and comorbidities (3C). Scientific directions will be distinct from concepts and approaches already pursued and consistent with the scientific priorities of the Office of AIDS Research (OAR). HIV-related 3Cs cause significant and different pathology in people with and without HIV. Development of preventive and therapeutic strategies based on understanding HIV-specific pathways and mechanisms, and implementing those strategies is critical, especially in pediatric and maternal populations. All pediatric and maternal populations will be appropriate for study as the focus is on HIV prevention and/or treatment research. A pipeline of innovative researchers from other fields of research including mathematics, engineering, computer science, and AI will bring new ideas and innovative approaches. This NOFO will advance research on an important public health problem by supporting transformative research on HIV 3Cs by investigators in the early stages of an independent career.

ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV
NICHD will advance its mission by using the DP2 mechanism to support early-career investigators conducting pioneering research on HIV-related chronic conditions, coinfections, and comorbidities (3C). Scientific directions will be distinct from concepts and approaches already pursued and consistent with the scientific priorities of the Office of AIDS Research (OAR). HIV-related 3Cs cause significant and different pathology in people with and without HIV. Development of preventive and therapeutic strategies based on understanding HIV-specific pathways and mechanisms, and implementing those strategies is critical, especially in pediatric and maternal populations. All pediatric and maternal populations will be appropriate for study as the focus is on HIV prevention and/or treatment research. A pipeline of innovative researchers from other fields of research including mathematics, engineering, computer science, and AI will bring new ideas and innovative approaches. This NOFO will advance research on an important public health problem by supporting transformative research on HIV 3Cs by investigators in the early stages of an independent career.
ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV
Open
National Institutes of Health
Health
Grant
State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others
2026-02-06