NIH Research Program Projects (Parent P01 Clinical Trial Optional)

Key Facts

Status: Open

Posted date: February 11, 2026

Opportunity ID: 361279

Opportunity number: PA-27-061

Opportunity category: Discretionary

Agency name: National Institutes of Health

Agency code: HHS-NIH11

Award floor: $0

Award ceiling: $0

Cost sharing required: No

Funding Instrument Types
  • Grant
Category of Funding Activity
  • Health
Eligible Applicants
  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Tools
Categories (use these for quoted searches)
  • agency_code:hhs_nih11
  • category_of_funding_activity:health
  • cost_sharing_or_matching_requirement:false
  • eligible_applicants:city_or_township_governments
  • eligible_applicants:county_governments
  • eligible_applicants:for_profit_organizations_other_than_small_businesses
  • eligible_applicants:independent_school_districts
  • eligible_applicants:native_american_tribal_governments_federally_recognized
  • eligible_applicants:native_american_tribal_organizations_other_than_federally_recognized_tribal_governments
  • eligible_applicants:nonprofits_having_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
  • eligible_applicants:nonprofits_that_do_not_have_a_501_c_3_status_with_the_irs_other_than_institutions_of_higher_education
  • eligible_applicants:others
  • eligible_applicants:private_institutions_of_higher_education
  • eligible_applicants:public_and_state_controlled_institutions_of_higher_education
  • eligible_applicants:public_housing_authoritiesindian_housing_authorities
  • eligible_applicants:small_businesses
  • eligible_applicants:special_district_governments
  • eligible_applicants:state_governments
  • funding_instrument_type:grant
  • opportunity_category:discretionary
  • status:open
Description

Through this Notice of Funding Opportunity (NOFO), the participating NIH Institutes, Centers, and offices (ICOs) invite applications for investigator-initiated Program Project (P01). A P01 supports a broadly based, multidisciplinary research program with a specific major scientific objective or theme. The proposed Program Project must be related to the programmatic interests of one or more of the participating ICs based on their scientific missions. Each application submitted in response to this NOFO must consist of at least two research projects and an Administrative Core. A P01 may include scientific cores, if needed for the proposed research. Applicants are strongly encouraged to reach out to awarding ICOs to discuss ICO-specific scientific core requirements at least 60 days prior to the receipt date: https://grants.nih.gov/funding/find-a-fit-for-your-research/nih-institutes-centers-offices. The projects included within the Program must share a common central scientific theme, focus, and/or an overall objective.

NIH Research Program Projects (Parent P01 Clinical Trial Optional)
Through this Notice of Funding Opportunity (NOFO), the participating NIH Institutes, Centers, and offices (ICOs) invite applications for investigator-initiated Program Project (P01). A P01 supports a broadly based, multidisciplinary research program with a specific major scientific objective or theme. The proposed Program Project must be related to the programmatic interests of one or more of the participating ICs based on their scientific missions. Each application submitted in response to this NOFO must consist of at least two research projects and an Administrative Core. A P01 may include scientific cores, if needed for the proposed research. Applicants are strongly encouraged to reach out to awarding ICOs to discuss ICO-specific scientific core requirements at least 60 days prior to the receipt date: https://grants.nih.gov/funding/find-a-fit-for-your-research/nih-institutes-centers-offices. The projects included within the Program must share a common central scientific theme, focus, and/or an overall objective.
NIH Research Program Projects (Parent P01 Clinical Trial Optional)
Open
National Institutes of Health
Health
Grant
State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For-profit organizations other than small businesses
Small businesses
Others
2026-02-11