Pathways for Regulatory Innovation and Strategic Modernization (PRISM)
Status: Forecasted
Posted date: March 31, 2026
Archive date: May 30, 2026
Close date: April 30, 2026
Opportunity ID: 361724
Opportunity number: RFA-FD-26-007
Opportunity category: Discretionary
Agency name: Food and Drug Administration
Agency code: HHS-FDA
Award floor: $0
Award ceiling: $1,300,000
Cost sharing required: No
Funding Instrument Types
- Cooperative Agreement
Category of Funding Activity
- Agriculture
- Consumer Protection
- Food and Nutrition
- Health
Eligible Applicants
- Others
Categories (use these for quoted searches)
- agency_code:hhs_fda
- category_of_funding_activity:agriculture
- category_of_funding_activity:consumer_protection
- category_of_funding_activity:food_and_nutrition
- category_of_funding_activity:health
- cost_sharing_or_matching_requirement:false
- eligible_applicants:others
- funding_instrument_type:cooperative_agreement
- opportunity_category:discretionary
- status:forecasted
The Pathways for Regulatory Innovation and Strategic Modernization (PRISM) cooperative agreement is intended to advance public health by strengthening the scientific, collaborative, and operational foundations needed to modernize regulatory oversight in an increasingly complex and rapidly evolving public health landscape. As innovation in medical products, diagnostics, foods, and digital health accelerates, our nation must continuously adapt its regulatory science approaches to ensure timely access to safe, effective, and high-quality products for the American public. PRISM is designed to support this modernization by enabling forward-looking, non-regulatory collaborations that align with the Commissioner’s strategic priorities and the Administration’s broader public health goals.PRISM provides a flexible, scalable approach to patient, consumer, industry, academia, and healthcare workforce engagement to generate applied scientific knowledge, tools, and approaches that enhance regulatory predictability, efficiency, and transparency. By leveraging independent expertise and real-world insights, PRISM bridges gaps between innovation and regulation to optimize uptake of emerging technologies, evolving consumer needs, and new sources of evidence such as real-world data and real-world evidence.