DoW Amyotrophic Lateral Sclerosis Research Program, Clinical Outcomes and Biomarkers Award
Status: Forecasted
Posted date: May 4, 2026
Archive date: October 30, 2026
Close date: September 30, 2026
Opportunity ID: 362194
Opportunity number: HT942526ALSRPCOBA
Opportunity category: Discretionary
Agency name: Dept. of the Army -- USAMRAA
Agency code: DOD-AMRAA
Award floor: $0
Award ceiling: $0
Cost sharing required: No
Funding Instrument Types
- Grant
Category of Funding Activity
- Science and Technology and other Research and Development
Eligible Applicants
- Unrestricted
Categories (use these for quoted searches)
- agency_code:dod_amraa
- category_of_funding_activity:science_and_technology_and_other_research_and_development
- cost_sharing_or_matching_requirement:false
- eligible_applicants:unrestricted
- funding_instrument_type:grant
- opportunity_category:discretionary
- status:forecasted
Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Clinical Outcomes and Biomarkers Award (COBA) supports the development and/or validation of clinical outcomes and biomarkers to enrich clinical trials in amyotrophic lateral sclerosis (ALS). Projects can be relevant to a specific therapy, a class of therapeutics, or to a specific ALS subtype (such as a particular genetic mutation) and do not have to broadly apply to all patients.Distinctive Features: To meet the intent of the funding opportunity, applications may address clinical biomarkers and/or clinical outcomes. This may include the identification, development, and/or validation of promising biomarkers for ALS, which may include, but are not limited to susceptibility/risk, diagnostic, monitoring/disease progression, prognostic, predictive, response, or safety biomarkers. Clinical Outcomes projects may focus on the identification, development, and/or validation of clinician-, observer-, or patient-reported, and/or performance outcome measures for ALS. Projects may include the optimization of current outcome measures already in use.Applications may utilize digital health measures, including wearable devices, smart-phone sensors, video or voice recordings, imaging studies, or other devices which record disease-relevant physiological data and/or outcomes.Community Collaboration is an important element of the FY26 ALSRP COBA. Applicants will be expected to articulate how the proposed research question or study design was informed by theALS lived experience community.