DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award
Status: Forecasted
Posted date: May 4, 2026
Archive date: October 30, 2026
Close date: September 30, 2026
Opportunity ID: 362195
Opportunity number: HT942526ALSRPPCTA
Opportunity category: Discretionary
Agency name: Dept. of the Army -- USAMRAA
Agency code: DOD-AMRAA
Award floor: $0
Award ceiling: $0
Cost sharing required: No
Funding Instrument Types
- Grant
Category of Funding Activity
- Science and Technology and other Research and Development
Eligible Applicants
- Unrestricted
Categories (use these for quoted searches)
- agency_code:dod_amraa
- category_of_funding_activity:science_and_technology_and_other_research_and_development
- cost_sharing_or_matching_requirement:false
- eligible_applicants:unrestricted
- funding_instrument_type:grant
- opportunity_category:discretionary
- status:forecasted
Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Pilot Clinical Trial Award (PCTA) supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of amyotrophic lateral sclerosis (ALS). Projects may range from phase 1 to small-scale phase 2 trials.Applications must address one of the following focus areas:· Biomarker-Driven Interventions: Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway.· Clinical Care: Improving aspects of clinical care and symptom management for ALS.Distinctive Features: Funding from this award mechanism must support a clinical trial. The clinical trial should begin no later than 12 months after the award date or 18 months for U.S. Food and Drug Administration (FDA)-regulated studies.Projects proposing a therapeutic intervention (drug, biologic, and/or device) must incorporate biomarkers specific to the intervention into the trial design.All pre-applications and applications are required to incorporate community collaboration, as described in Section 3.2.2, to optimize research impact.Applications must include a detailed Regulatory Strategy plan that outlines the approach for obtaining regulatory approvals, if required, specifically for the funded portion of the study. In addition, applications must provide a separate Transition Plan that describes how the outcomes of the study will be advanced to the next phase of development, beyond the scope of the funded work.