DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award
Status: Forecasted
Posted date: May 4, 2026
Archive date: October 30, 2026
Close date: September 30, 2026
Opportunity ID: 362196
Opportunity number: HT942526ALSRPTDA
Opportunity category: Discretionary
Agency name: Dept. of the Army -- USAMRAA
Agency code: DOD-AMRAA
Award floor: $0
Award ceiling: $0
Cost sharing required: No
Funding Instrument Types
- Grant
Category of Funding Activity
- Science and Technology and other Research and Development
Eligible Applicants
- Unrestricted
Categories (use these for quoted searches)
- agency_code:dod_amraa
- category_of_funding_activity:science_and_technology_and_other_research_and_development
- cost_sharing_or_matching_requirement:false
- eligible_applicants:unrestricted
- funding_instrument_type:grant
- opportunity_category:discretionary
- status:forecasted
Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Therapeutic Development Award (TDA) supports research ranging from preclinical validation of therapeutic leads through U.S. Food and Drug Administration (FDA) Investigational New Drug (IND)-enabling studies. The proposed studies are expected to be empirical in nature and product-driven. Applicants with limited amyotrophic lateral sclerosis (ALS) experience are strongly encouraged to include collaborators with substantial experience in the relevant ALS model systems, endpoints and pathophysiology.Applications supported by this award must begin with lead compounds in hand and must already demonstrate proof-of-concept efficacy data in at least one appropriate preclinical model system of ALS, including whole-animal and cellular model systems.Distinctive Features: Mechanism-specific, predictive/cohort-selective, target engagement and pharmacodynamic biomarker development, in parallel to the main therapeutic effort, is a critical component of the FY26 ALSRP Therapeutic Development Award. If appropriate mechanism-specific biomarkers are already available or currently in development, how the existing biomarkers will improve trial design, patient selection, and efficiency or interpretation of the proposed ALS therapeutic approach must be apparent in the application. Development of biomarkers for the purposes of diagnosis, prognosis, or measurement of general disease progression without consideration of the therapeutic development process will not be supported.Therapeutic candidates which have already been granted an IND are not appropriate for this mechanism.